The aim of present study was to develop Microballoons of Ciprofloxacin hydrochloride to treat H.pylori infections and gastro-intestinal anthrax caused by B.anthracis. in order to achieve, Materials and method: Microballoons of ciprofloxacin hydrochloride were prepared by emulsion solvent diffusion method using polymer such as ethyl cellulose (EC) and eudragit S100 (EU) in different ratios (drug: polymer 1:1, 1:2, 1:3). The microballoons were characterized for their shape and surface morphology by optical and scanning electron microscopy, drug loading, buoyancy time and infrared spectroscopy (FT-IR) for the compatibility study. Key findings: The micromeritic properties of microballoons were found to be much improved .The in-vitro drug release were studied by USPXXIII (basket type). The prepared microballoons exhibited prolonged drug release (>12 hrs) and remained buoyant for > 12 hrs. The mean particle size increased and drug release rate decreased at higher polymer concentration. The release kinetics studies were fit into zero order and Fickian diffusion controlled mechanism was observed. Conclusion: from the obtained results we can achieve an extended retention in the upper GIT, which may result in enhanced absorption, decreased dosing interval and improved bioavailability.
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